Denosy® contains S-adenosylmethionine (SAMe), a precursor to the potent antioxidant Glutathione that protects hepatic cells from toxins and death. It is recommended to improve hepatic glutathione levels in patients to help maintain and protect liver function^3,4. Denosyl® may also be used in other areas of tissue oxidative injury caused by certain toxins or drugs which are related to reduced glutathione concentrations.⁴ Denosy®, however, goes beyond increasing glutathione levels and has been shown to protect liver cells from cell death and may be useful in cell regeneration.^1,5

• Aides aux mécanismes de désintoxication du foie chez les chiens et les chats
• Peut être utilisé dans d'autres zones de lésions oxydatives des tissus et de fragilité des cellules sanguines causée par certains médicaments
• Peut protéger contre les effets négatifs sur le foie causés par certains médicaments
• Very high safety profile ^1,3,4
• Also, supports healthy brain function in senior dogs

Le foie

The liver is one of the largest organs in the body and performs many life-essential functions. It produces a vast number of hormones, enzymes, proteins, and other substances important for your pet’s life and well-being. It also detoxifies and removes waste products in the bloodstream by changing them to a form that can be eliminated. This filtering of waste products is important because toxins can damage the membranes of cells in the liver and other organs. The most important liver “detoxifier” is glutathione, a potent antioxidant and the liver’s first line of defense.

Thérapie antioxydante

Both dogs and cats make glutathione from S-adenosylmethionine (SAMe). SAMe is formed naturally by the liver from the amino acid methionine, found in your pet’s diet. When the liver is compromised, production of SAMe decreases resulting in less glutathione.1 This further compromises liver function. A study of dogs and cats with various liver function problems reported that many had low liver glutathione levels.²

Ingrédients

Contient l'ingrédient actif S-adenosylmethionine (SAMe) dans un comprimé enrobé entérique.

Quand utiliser

PAW Denosyl® is used as adjunctive treatment for liver diseases or dysfunction, such as the following:

• Hépatite chronique
• Lipidosis hépatique
• Cholangiohepatite
• Toxicité par le paracetamol
• Corticosteroid use (Note: does not prevent corticosteroid-induced hepatic vacuolar change)
• Autres hépatopathies aiguës ou chroniques, y compris les hépatotoxines et la néoplasie

Dosage et administration

Absorption of Denosyl® is decreased when it is given with a meal. For optimal absorption, administer Denosyl® at least one hour before feeding your pet. For owners who find it difficult to administer tablets to their pets, Denosyl®tablet(s) may be disguised in a small bite of moist food. It is not necessary to withhold water from your pet when giving Denosyl®
In cats, tablets or capsules can “stick” in the throat instead of passing into the stomach. Therefore, cat owners should gently administer a small amount of water (ask your veterinarian for details) immediately following tablet administration to aid swallowing.
 
Denosyl® tablets should not be broken as the enteric coating of the Denosyl® tablet protects the active ingredient from destruction while in the stomach.
 
Le nombre de comprimés peut être progressivement réduit ou augmenté à tout moment en fonction des besoins de l'animal. En augmentant ou en diminuant la dose, les ajustements doivent être effectués dans les augmentations complètes des comprimés.
 
De nombreux animaux de compagnie sont maintenus à long terme tous les jours ou tous les trois jours de l'administration.

Les références

1. Center SA. Proceedings of the 18th ACVIM, Seattle, WA, 2000; 550-552.
2. Center SA. Proceedings of TNAVC, Orlando, FL 2001; 218-219.
3. Center SA, Warner K, Hoffman WE, et al. Am J Vet Res 2005;66(2):330-341.
4. Centre SA, Randolph JF, Warner K, et al. J Vet Intern Med 2005; 19: 303-314.
5. Webster CRL, Boria P, Usechak P, Anwer MS. Vet Therapeutics 2002; 3 (4): 474-484.
6. Center SA, Warner KL, Erb HN. Am J Vet Res 2002;63(8):1187-1197.